BIOCILLIN 4.5
BIOCILLIN 4.5
COMPOSITION
Piperacillin 4 g + Tazobactam 0.5 g (Injection)
Category
Antibiotic, Extended-spectrum Penicillin
| Packing |
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ENQUIRY
Indications
BIOCILLIN 4.5 is a powerful combination antibiotic injection used in hospitals to treat serious and life-threatening bacterial infections. It is one of the most trusted antibiotics in critical care settings because it covers a very wide range of bacteria, including some of the hardest ones to treat. It is prescribed for:
Severe Systemic Infections: Used when a bacterial infection has spread beyond a single organ and is affecting the body more widely, requiring a strong and broad-coverage antibiotic.
Hospital-Acquired Pneumonia: Effective in treating lung infections picked up in hospitals or ICUs, especially those caused by resistant bacteria like Pseudomonas aeruginosa.
Sepsis: Prescribed in serious bloodstream infections where fast bacterial clearance is critical to saving the patient’s life.
Intra-Abdominal Infections: Treats bacterial infections inside the stomach cavity, including peritonitis and infections after abdominal surgeries.
Urinary Tract Infections (UTIs): Used for complicated UTIs caused by bacteria that have not responded to simpler antibiotics.
Skin and Soft Tissue Infections: Treats deep or serious wound infections, diabetic foot infections, and skin infections caused by resistant bacteria.
Gynecological Infections: Used in severe pelvic infections and infections of the female reproductive organs.
Febrile Neutropenia: Commonly used in cancer patients with low white blood cell counts who develop fever due to a bacterial infection — a situation that needs immediate and strong antibiotic coverage.
Severe Systemic Infections: Used when a bacterial infection has spread beyond a single organ and is affecting the body more widely, requiring a strong and broad-coverage antibiotic.
Hospital-Acquired Pneumonia: Effective in treating lung infections picked up in hospitals or ICUs, especially those caused by resistant bacteria like Pseudomonas aeruginosa.
Sepsis: Prescribed in serious bloodstream infections where fast bacterial clearance is critical to saving the patient’s life.
Intra-Abdominal Infections: Treats bacterial infections inside the stomach cavity, including peritonitis and infections after abdominal surgeries.
Urinary Tract Infections (UTIs): Used for complicated UTIs caused by bacteria that have not responded to simpler antibiotics.
Skin and Soft Tissue Infections: Treats deep or serious wound infections, diabetic foot infections, and skin infections caused by resistant bacteria.
Gynecological Infections: Used in severe pelvic infections and infections of the female reproductive organs.
Febrile Neutropenia: Commonly used in cancer patients with low white blood cell counts who develop fever due to a bacterial infection — a situation that needs immediate and strong antibiotic coverage.
Uses
BIOCILLIN 4.5 combines Piperacillin, an extended-spectrum penicillin antibiotic, with Tazobactam, a beta-lactamase inhibitor. In simple terms, some bacteria protect themselves by producing enzymes that break down antibiotics before they can work. Tazobactam blocks these enzymes so Piperacillin can get through and kill the bacteria. Together, they cover a very wide range of harmful bacteria, including gram-positive, gram-negative, and anaerobic types.
Treats Severe Systemic Infections: The combination is strong enough to handle serious infections that have spread through the body and need immediate control.
Effective in ICU Patients with Pneumonia or Sepsis: One of the most commonly used antibiotics in intensive care units for critically ill patients dealing with pneumonia, sepsis, or multi-organ infections.
Broad-Spectrum Coverage: Covers gram-positive bacteria, gram-negative bacteria, and anaerobic bacteria — meaning it works against a very wide variety of infection-causing organisms in one go.
Used in Intra-Abdominal Infections: Particularly effective in the stomach and gut area where mixed bacterial infections (involving multiple types of bacteria) are common.
Covers Pseudomonas: This is one of the hardest hospital bacteria to treat. BIOCILLIN 4.5 has strong activity against Pseudomonas aeruginosa, making it a key choice in ICU and post-surgical infections where this bacteria is a concern.
Tazobactam’s Role: By protecting Piperacillin from being broken down, Tazobactam extends the antibiotic’s reach and makes the combination effective even against resistant bacterial strains.
Treats Severe Systemic Infections: The combination is strong enough to handle serious infections that have spread through the body and need immediate control.
Effective in ICU Patients with Pneumonia or Sepsis: One of the most commonly used antibiotics in intensive care units for critically ill patients dealing with pneumonia, sepsis, or multi-organ infections.
Broad-Spectrum Coverage: Covers gram-positive bacteria, gram-negative bacteria, and anaerobic bacteria — meaning it works against a very wide variety of infection-causing organisms in one go.
Used in Intra-Abdominal Infections: Particularly effective in the stomach and gut area where mixed bacterial infections (involving multiple types of bacteria) are common.
Covers Pseudomonas: This is one of the hardest hospital bacteria to treat. BIOCILLIN 4.5 has strong activity against Pseudomonas aeruginosa, making it a key choice in ICU and post-surgical infections where this bacteria is a concern.
Tazobactam’s Role: By protecting Piperacillin from being broken down, Tazobactam extends the antibiotic’s reach and makes the combination effective even against resistant bacterial strains.
Dosage & Storage
Dosage: The dose is decided by the treating doctor based on the type and severity of the infection, the patient’s kidney function, body weight, and overall clinical condition.
Route of Administration: Given only as a slow intravenous (IV) infusion by a qualified doctor or nurse in a hospital or clinical setting. Not for IM use.
Reconstitution: The powder must be dissolved in a suitable diluent and further diluted in an IV bag before administration. Always follow the preparation and dilution instructions provided by the medical team. Infusion Time: Usually given as a 30-minute IV infusion. The timing should follow the doctor’s instructions exactly.
Storage: Store the dry vial at room temperature between 15°C and 30°C, in a cool and dry place away from moisture.
Protect from Light: Keep in original packaging away from direct sunlight and heat.
After Reconstitution: Use the prepared solution within the recommended time frame. Do not store mixed solution for later use unless clearly instructed.
Keep Out of Reach: Store safely away from children and pets at all times.
Route of Administration: Given only as a slow intravenous (IV) infusion by a qualified doctor or nurse in a hospital or clinical setting. Not for IM use.
Reconstitution: The powder must be dissolved in a suitable diluent and further diluted in an IV bag before administration. Always follow the preparation and dilution instructions provided by the medical team. Infusion Time: Usually given as a 30-minute IV infusion. The timing should follow the doctor’s instructions exactly.
Storage: Store the dry vial at room temperature between 15°C and 30°C, in a cool and dry place away from moisture.
Protect from Light: Keep in original packaging away from direct sunlight and heat.
After Reconstitution: Use the prepared solution within the recommended time frame. Do not store mixed solution for later use unless clearly instructed.
Keep Out of Reach: Store safely away from children and pets at all times.
Directions For Use
Hospital Use Only: BIOCILLIN 4.5 is strictly for use in a hospital or clinical setting. It must be prepared and given by a trained medical professional and is not suitable for home use.
Do Not Self-Administer: This injection should never be prepared or given by the patient themselves. Always rely on a qualified nurse or doctor.
Check Before Use: After reconstitution, inspect the solution — it should be clear and free from any floating particles or discoloration. Do not use if it looks cloudy or has changed color.
Complete the Full Course: Even if the patient starts feeling better after a few doses, always complete the full antibiotic course as prescribed. Stopping early can cause the infection to return and may make bacteria more resistant to treatment.
Fixed Intervals: Doses should be given at evenly spaced intervals throughout the day to keep the antibiotic working at a steady level in the body.
Missed Dose: If a scheduled dose is skipped, inform the treating doctor immediately. Never double the next dose to compensate.
Monitor During Treatment: Patients receiving BIOCILLIN 4.5 are usually monitored for kidney function, blood counts, and electrolyte levels during longer treatment courses.
Do Not Self-Administer: This injection should never be prepared or given by the patient themselves. Always rely on a qualified nurse or doctor.
Check Before Use: After reconstitution, inspect the solution — it should be clear and free from any floating particles or discoloration. Do not use if it looks cloudy or has changed color.
Complete the Full Course: Even if the patient starts feeling better after a few doses, always complete the full antibiotic course as prescribed. Stopping early can cause the infection to return and may make bacteria more resistant to treatment.
Fixed Intervals: Doses should be given at evenly spaced intervals throughout the day to keep the antibiotic working at a steady level in the body.
Missed Dose: If a scheduled dose is skipped, inform the treating doctor immediately. Never double the next dose to compensate.
Monitor During Treatment: Patients receiving BIOCILLIN 4.5 are usually monitored for kidney function, blood counts, and electrolyte levels during longer treatment courses.
Precautions
Before starting BIOCILLIN 4.5, the doctor must be informed about the following:
Penicillin or Beta-Lactam Allergy: Do not use if you have a known allergy to Piperacillin, Tazobactam, any penicillin, or cephalosporin antibiotic. Always share your full allergy history before starting treatment.
Kidney Problems: Piperacillin is mainly removed from the body through the kidneys. Patients with kidney disease need dose adjustments and regular monitoring throughout the course.
Liver Disease: Use with caution in patients with existing liver problems. Blood tests may be needed periodically. Electrolyte Levels: BIOCILLIN 4.5 contains sodium, which may affect potassium and sodium levels in the blood. Regular blood tests are recommended, especially in patients with heart or kidney conditions.
Bleeding Risk: Piperacillin can sometimes affect platelet function. Patients on blood thinners or those with bleeding disorders need careful monitoring.
Pregnancy & Breastfeeding: Use only if clearly needed and as prescribed by the doctor during pregnancy or while nursing.
Other Medications: Tell your doctor about all current medicines, especially blood thinners, methotrexate, or other antibiotics, as these may interact with BIOCILLIN 4.5.
Prolonged Use: Long-term antibiotic use can sometimes lead to secondary infections from organisms not covered by this medicine. Regular check-ups are important during extended treatment.
Penicillin or Beta-Lactam Allergy: Do not use if you have a known allergy to Piperacillin, Tazobactam, any penicillin, or cephalosporin antibiotic. Always share your full allergy history before starting treatment.
Kidney Problems: Piperacillin is mainly removed from the body through the kidneys. Patients with kidney disease need dose adjustments and regular monitoring throughout the course.
Liver Disease: Use with caution in patients with existing liver problems. Blood tests may be needed periodically. Electrolyte Levels: BIOCILLIN 4.5 contains sodium, which may affect potassium and sodium levels in the blood. Regular blood tests are recommended, especially in patients with heart or kidney conditions.
Bleeding Risk: Piperacillin can sometimes affect platelet function. Patients on blood thinners or those with bleeding disorders need careful monitoring.
Pregnancy & Breastfeeding: Use only if clearly needed and as prescribed by the doctor during pregnancy or while nursing.
Other Medications: Tell your doctor about all current medicines, especially blood thinners, methotrexate, or other antibiotics, as these may interact with BIOCILLIN 4.5.
Prolonged Use: Long-term antibiotic use can sometimes lead to secondary infections from organisms not covered by this medicine. Regular check-ups are important during extended treatment.
Side Effects
Rash
Diarrhea
Thrombophlebitis
Altered kidney function
Injection site pain
Diarrhea
Thrombophlebitis
Altered kidney function
Injection site pain
Medical Disclaimer
The information provided here is for educational and informational purposes only and is not a substitute for professional medical advice. Always consult a healthcare professional for medical advice, diagnosis, or treatment.
BIOCILLIN 4.5 is a prescription-only injectable and must be administered strictly under the supervision of a licensed medical professional in a hospital or clinical setting. Agnes Life Sciences does not claim that this or any of its products can diagnose, treat, cure, or prevent any disease.
BIOCILLIN 4.5 is a prescription-only injectable and must be administered strictly under the supervision of a licensed medical professional in a hospital or clinical setting. Agnes Life Sciences does not claim that this or any of its products can diagnose, treat, cure, or prevent any disease.
Indications
BIOCILLIN 4.5 is a powerful combination antibiotic injection used in hospitals to treat serious and life-threatening bacterial infections. It is one of the most trusted antibiotics in critical care settings because it covers a very wide range of bacteria, including some of the hardest ones to treat. It is prescribed for:
Severe Systemic Infections: Used when a bacterial infection has spread beyond a single organ and is affecting the body more widely, requiring a strong and broad-coverage antibiotic.
Hospital-Acquired Pneumonia: Effective in treating lung infections picked up in hospitals or ICUs, especially those caused by resistant bacteria like Pseudomonas aeruginosa.
Sepsis: Prescribed in serious bloodstream infections where fast bacterial clearance is critical to saving the patient’s life.
Intra-Abdominal Infections: Treats bacterial infections inside the stomach cavity, including peritonitis and infections after abdominal surgeries.
Urinary Tract Infections (UTIs): Used for complicated UTIs caused by bacteria that have not responded to simpler antibiotics.
Skin and Soft Tissue Infections: Treats deep or serious wound infections, diabetic foot infections, and skin infections caused by resistant bacteria.
Gynecological Infections: Used in severe pelvic infections and infections of the female reproductive organs.
Febrile Neutropenia: Commonly used in cancer patients with low white blood cell counts who develop fever due to a bacterial infection — a situation that needs immediate and strong antibiotic coverage.
Severe Systemic Infections: Used when a bacterial infection has spread beyond a single organ and is affecting the body more widely, requiring a strong and broad-coverage antibiotic.
Hospital-Acquired Pneumonia: Effective in treating lung infections picked up in hospitals or ICUs, especially those caused by resistant bacteria like Pseudomonas aeruginosa.
Sepsis: Prescribed in serious bloodstream infections where fast bacterial clearance is critical to saving the patient’s life.
Intra-Abdominal Infections: Treats bacterial infections inside the stomach cavity, including peritonitis and infections after abdominal surgeries.
Urinary Tract Infections (UTIs): Used for complicated UTIs caused by bacteria that have not responded to simpler antibiotics.
Skin and Soft Tissue Infections: Treats deep or serious wound infections, diabetic foot infections, and skin infections caused by resistant bacteria.
Gynecological Infections: Used in severe pelvic infections and infections of the female reproductive organs.
Febrile Neutropenia: Commonly used in cancer patients with low white blood cell counts who develop fever due to a bacterial infection — a situation that needs immediate and strong antibiotic coverage.
Uses
BIOCILLIN 4.5 combines Piperacillin, an extended-spectrum penicillin antibiotic, with Tazobactam, a beta-lactamase inhibitor. In simple terms, some bacteria protect themselves by producing enzymes that break down antibiotics before they can work. Tazobactam blocks these enzymes so Piperacillin can get through and kill the bacteria. Together, they cover a very wide range of harmful bacteria, including gram-positive, gram-negative, and anaerobic types.
Treats Severe Systemic Infections: The combination is strong enough to handle serious infections that have spread through the body and need immediate control.
Effective in ICU Patients with Pneumonia or Sepsis: One of the most commonly used antibiotics in intensive care units for critically ill patients dealing with pneumonia, sepsis, or multi-organ infections.
Broad-Spectrum Coverage: Covers gram-positive bacteria, gram-negative bacteria, and anaerobic bacteria — meaning it works against a very wide variety of infection-causing organisms in one go.
Used in Intra-Abdominal Infections: Particularly effective in the stomach and gut area where mixed bacterial infections (involving multiple types of bacteria) are common.
Covers Pseudomonas: This is one of the hardest hospital bacteria to treat. BIOCILLIN 4.5 has strong activity against Pseudomonas aeruginosa, making it a key choice in ICU and post-surgical infections where this bacteria is a concern.
Tazobactam’s Role: By protecting Piperacillin from being broken down, Tazobactam extends the antibiotic’s reach and makes the combination effective even against resistant bacterial strains.
Treats Severe Systemic Infections: The combination is strong enough to handle serious infections that have spread through the body and need immediate control.
Effective in ICU Patients with Pneumonia or Sepsis: One of the most commonly used antibiotics in intensive care units for critically ill patients dealing with pneumonia, sepsis, or multi-organ infections.
Broad-Spectrum Coverage: Covers gram-positive bacteria, gram-negative bacteria, and anaerobic bacteria — meaning it works against a very wide variety of infection-causing organisms in one go.
Used in Intra-Abdominal Infections: Particularly effective in the stomach and gut area where mixed bacterial infections (involving multiple types of bacteria) are common.
Covers Pseudomonas: This is one of the hardest hospital bacteria to treat. BIOCILLIN 4.5 has strong activity against Pseudomonas aeruginosa, making it a key choice in ICU and post-surgical infections where this bacteria is a concern.
Tazobactam’s Role: By protecting Piperacillin from being broken down, Tazobactam extends the antibiotic’s reach and makes the combination effective even against resistant bacterial strains.
Dosage & Storage
Dosage: The dose is decided by the treating doctor based on the type and severity of the infection, the patient’s kidney function, body weight, and overall clinical condition.
Route of Administration: Given only as a slow intravenous (IV) infusion by a qualified doctor or nurse in a hospital or clinical setting. Not for IM use.
Reconstitution: The powder must be dissolved in a suitable diluent and further diluted in an IV bag before administration. Always follow the preparation and dilution instructions provided by the medical team. Infusion Time: Usually given as a 30-minute IV infusion. The timing should follow the doctor’s instructions exactly.
Storage: Store the dry vial at room temperature between 15°C and 30°C, in a cool and dry place away from moisture.
Protect from Light: Keep in original packaging away from direct sunlight and heat.
After Reconstitution: Use the prepared solution within the recommended time frame. Do not store mixed solution for later use unless clearly instructed.
Keep Out of Reach: Store safely away from children and pets at all times.
Route of Administration: Given only as a slow intravenous (IV) infusion by a qualified doctor or nurse in a hospital or clinical setting. Not for IM use.
Reconstitution: The powder must be dissolved in a suitable diluent and further diluted in an IV bag before administration. Always follow the preparation and dilution instructions provided by the medical team. Infusion Time: Usually given as a 30-minute IV infusion. The timing should follow the doctor’s instructions exactly.
Storage: Store the dry vial at room temperature between 15°C and 30°C, in a cool and dry place away from moisture.
Protect from Light: Keep in original packaging away from direct sunlight and heat.
After Reconstitution: Use the prepared solution within the recommended time frame. Do not store mixed solution for later use unless clearly instructed.
Keep Out of Reach: Store safely away from children and pets at all times.
Directions For Use
Hospital Use Only: BIOCILLIN 4.5 is strictly for use in a hospital or clinical setting. It must be prepared and given by a trained medical professional and is not suitable for home use.
Do Not Self-Administer: This injection should never be prepared or given by the patient themselves. Always rely on a qualified nurse or doctor.
Check Before Use: After reconstitution, inspect the solution — it should be clear and free from any floating particles or discoloration. Do not use if it looks cloudy or has changed color.
Complete the Full Course: Even if the patient starts feeling better after a few doses, always complete the full antibiotic course as prescribed. Stopping early can cause the infection to return and may make bacteria more resistant to treatment.
Fixed Intervals: Doses should be given at evenly spaced intervals throughout the day to keep the antibiotic working at a steady level in the body.
Missed Dose: If a scheduled dose is skipped, inform the treating doctor immediately. Never double the next dose to compensate.
Monitor During Treatment: Patients receiving BIOCILLIN 4.5 are usually monitored for kidney function, blood counts, and electrolyte levels during longer treatment courses.
Do Not Self-Administer: This injection should never be prepared or given by the patient themselves. Always rely on a qualified nurse or doctor.
Check Before Use: After reconstitution, inspect the solution — it should be clear and free from any floating particles or discoloration. Do not use if it looks cloudy or has changed color.
Complete the Full Course: Even if the patient starts feeling better after a few doses, always complete the full antibiotic course as prescribed. Stopping early can cause the infection to return and may make bacteria more resistant to treatment.
Fixed Intervals: Doses should be given at evenly spaced intervals throughout the day to keep the antibiotic working at a steady level in the body.
Missed Dose: If a scheduled dose is skipped, inform the treating doctor immediately. Never double the next dose to compensate.
Monitor During Treatment: Patients receiving BIOCILLIN 4.5 are usually monitored for kidney function, blood counts, and electrolyte levels during longer treatment courses.
Precautions
Before starting BIOCILLIN 4.5, the doctor must be informed about the following:
Penicillin or Beta-Lactam Allergy: Do not use if you have a known allergy to Piperacillin, Tazobactam, any penicillin, or cephalosporin antibiotic. Always share your full allergy history before starting treatment.
Kidney Problems: Piperacillin is mainly removed from the body through the kidneys. Patients with kidney disease need dose adjustments and regular monitoring throughout the course.
Liver Disease: Use with caution in patients with existing liver problems. Blood tests may be needed periodically. Electrolyte Levels: BIOCILLIN 4.5 contains sodium, which may affect potassium and sodium levels in the blood. Regular blood tests are recommended, especially in patients with heart or kidney conditions.
Bleeding Risk: Piperacillin can sometimes affect platelet function. Patients on blood thinners or those with bleeding disorders need careful monitoring.
Pregnancy & Breastfeeding: Use only if clearly needed and as prescribed by the doctor during pregnancy or while nursing.
Other Medications: Tell your doctor about all current medicines, especially blood thinners, methotrexate, or other antibiotics, as these may interact with BIOCILLIN 4.5.
Prolonged Use: Long-term antibiotic use can sometimes lead to secondary infections from organisms not covered by this medicine. Regular check-ups are important during extended treatment.
Penicillin or Beta-Lactam Allergy: Do not use if you have a known allergy to Piperacillin, Tazobactam, any penicillin, or cephalosporin antibiotic. Always share your full allergy history before starting treatment.
Kidney Problems: Piperacillin is mainly removed from the body through the kidneys. Patients with kidney disease need dose adjustments and regular monitoring throughout the course.
Liver Disease: Use with caution in patients with existing liver problems. Blood tests may be needed periodically. Electrolyte Levels: BIOCILLIN 4.5 contains sodium, which may affect potassium and sodium levels in the blood. Regular blood tests are recommended, especially in patients with heart or kidney conditions.
Bleeding Risk: Piperacillin can sometimes affect platelet function. Patients on blood thinners or those with bleeding disorders need careful monitoring.
Pregnancy & Breastfeeding: Use only if clearly needed and as prescribed by the doctor during pregnancy or while nursing.
Other Medications: Tell your doctor about all current medicines, especially blood thinners, methotrexate, or other antibiotics, as these may interact with BIOCILLIN 4.5.
Prolonged Use: Long-term antibiotic use can sometimes lead to secondary infections from organisms not covered by this medicine. Regular check-ups are important during extended treatment.
Side Effects
Rash
Diarrhea
Thrombophlebitis
Altered kidney function
Injection site pain
Diarrhea
Thrombophlebitis
Altered kidney function
Injection site pain
Medical Disclaimer
The information provided here is for educational and informational purposes only and is not a substitute for professional medical advice. Always consult a healthcare professional for medical advice, diagnosis, or treatment.
BIOCILLIN 4.5 is a prescription-only injectable and must be administered strictly under the supervision of a licensed medical professional in a hospital or clinical setting. Agnes Life Sciences does not claim that this or any of its products can diagnose, treat, cure, or prevent any disease.
BIOCILLIN 4.5 is a prescription-only injectable and must be administered strictly under the supervision of a licensed medical professional in a hospital or clinical setting. Agnes Life Sciences does not claim that this or any of its products can diagnose, treat, cure, or prevent any disease.
